1121-83-1, 5,5-Dimethyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 3-iodo-N-(3,4,5-trifluorophenyl)-4,5,6,7-tetrahydropyrazolo[l,5- a]pyridine-5-carboxamide (compound lh, 100 mg, 0.24 mmol), 5,5-dimethyloxazolidin-2-one (41 mg, 0.36 mmol), irara-A.N’-dimethylcyclohexane-l-diamine (3 mg, 0.024 mmol) and Cul (45 mg, 0.24 mmol) in DMSO (3 mL) was added K2C03 (131 mg, 0.95 mmol). The reaction mixture was stirred at 80 C for 12 hours, and then partitioned between EtOAc (50 mL) and water (50 mL). The organic layer was washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by prep-HPLC to give 3-(5,5- dimethyl-2-oxo-oxazolidin-3-yl)-N-(3,4,5-trifluorophenyl)-4,5,6,7-tetrahydropyrazolo[l,5- a]pyridine-5-carboxamide (Example 2, 62 mg) as a white solid. 1H NMR (400 MHz, CDC13) delta 8.94 (br. s., 1H), 7.37 – 7.48 (m, 3 H), 4.04 – 4.20 (m, 2 H), 3.79 (d, 1H), 3.64 (d, 1H), 3.34 (dd, 1H), 2.89 – 3.04 (m, 2 H), 2.58 – 2.70 (m, 1H), 2.20 – 2.33 (m, 1H), 1.61 (s, 6 H). MS obsd. (ESI+) [(M+H)+]: 409.
1121-83-1, 1121-83-1 5,5-Dimethyloxazolidin-2-one 136892, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HU, Taishan; SHEN, Hong; HAN, Xingchun; (45 pag.)WO2018/11100; (2018); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem