108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Di-tert-butyl azodicarboxylate (0.56 g, 2.43 mmol) was added portionwise to a mixture of 5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester (0.5 g, 2.0 mmol), (i?)-l-boc-2,2-dimethyl-4-hydroxymethyl-oxazolidine (0.49 g, 2.1 mmol) andtriphenylphosphine (0.64 g, 2.4 mmol) in THF (10 mL) at 0 C. The mixture was stirred at room temperature for 30 minutes. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (silica; DCM in heptane 50/50 to 100/0). Desired fractions were collected and the solvent evaporated in vacuo to yield (i?)-4-(5- ethoxycarbonyl-3-phenoxymethyl-pyrazol-l-ylmethyl)-2,2-dimethyl-oxazolidine-3- carboxylic acid tert-butyl ester (0.91 g, 98 % yield) as a clear oil., 108149-63-9
108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; STAUFFER, Shaun, R.; BARTOLOME-NEBREDA, Jose, Manuel; CONDE-CEIDE, Susana; MACDONALD, Gregor, James; TONG, Han, Min; JONES, Carrie, K.; ALCAZAR-VACA, Manuel, Jesus; ANDRES-GIL, Jose, Ignacio; MALOSH, Chrysa; WO2012/83224; (2012); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem