The Role of the Achiral Template in Enantioselective Transformations. Radical Conjugate Additions to α-Methacrylates Followed by Hydrogen Atom Transfer was written by Sibi, Mukund P.; Sausker, Justin B.. And the article was included in Journal of the American Chemical Society on February 13,2002.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:
We have evaluated various achiral templates in conjunction with chiral Lewis acids in the conjugate addition of nucleophilic radicals to α-methacrylates followed by enantioselective H-atom transfer. Of these, a novel naphthosultam template I gave high enantioselectivity in the H-atom-transfer reactions with ee’s up to 90%. A chiral Lewis acid derived from MgBr2 and a bisoxazoline gave the highest selectivity in the enantioselective hydrogen-atom-transfer reactions. Non-C2 sym. oxazolines have also been examined as ligands, and of these, compound II gave optimal results (87% yield and 80% ee). Insights into rotamer control in α-substituted acrylates and the critical role of the tetrahedral sulfone moiety in realizing high selectivity are discussed. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).
(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol
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