On June 30, 2016, Shiers, Jason John; Watts, John Paul; Onions, Stuart Thomas; Abdul Quddus, Mohammed; Wrigglesworth, Joseph William; Sambrook-Smith, Colin Peter; Naylor, Alan; Londesbrough, Derek published a patent.Synthetic Route of 168297-86-7 The title of the patent was Preparation of pyridine, pyridazine and triazine derivatives for the treatment of cancer and/or other diseases. And the patent contained the following:
Title compounds I [one of Q1 and Q2 = N and the other = CH, or both Q1 and Q2 = N, and Q3 = CH; or Q1 , Q2 and Q3 = N; A = (un)substituted five- or six-membered aromatic ring; R1 = aliphatic carbocyclic or heterocyclic ring; R2 = H, alkyl or halo; R3 = aryl or heteroaryl; R5 and R6 independently = H or alkyl] and their pharmaceutically acceptable salts, are prepared and disclosed for the treatment of cancer. Thus, II was prepared in a multi-step synthesis starting from Et 2-(trans-4-aminocyclohexyl)acetate hydrochloride with CbzCl. Compounds of the invention were tested for their inhibitory activity in Akt activation assay, e.g., compound II showed IC50 value of 780 nM, 110 nM and 15 nM against Akt1 and Akt2 and Akt3. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7
The Article related to pyridine pyridazine triazine preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem