Chemistry can be defined as the study of matter and the changes it undergoes. Reference of 95715-86-9. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.Reference of 95715-86-9, Name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, molecular formula is C12H21NO5, introducing its new discovery.
The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand. A general approach towards a new class of seven-membered ring amino acids is described starting from (S)-tribenzyl glutamic acid gamma-aldehyde, which reacts with beta-keto phosphonates to generate the Horner-Wadsworth-Emmons product. In the presence of H2 and a Pd catalyst, a four-step process occurs involving double-bond hydrogenation, hydrogenolysis of three benzyl protecting groups, imine formation, and reductive amination to produce the 7-substituted azepane carboxylic acid in good overall yield and with good to excellent diastereomeric ratios. An amino function can be introduced in the 7-position as an additional orthogonal chemical handle for readily generating diversity on the cyclic amino acid scaffold by using a beta-keto phosphonate derived from amino acids. A cyclic RGD (Arg-Gly-Asp) pentapeptide analogue containing this new class of noncoded amino acids was also prepared by microwave-assisted cyclization, showing a promising activity as alphavbeta3 integrin inhibitor.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 95715-86-9. Reference of 95715-86-9
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2501NO – PubChem