Qin, Xiao-Ting published the artcileSynthesis of Chiral Nine-Membered N-Heterocycles through Silver(I)-Promoted Cycloaddition and Rearrangement from N-Vinyl-α,β-Unsaturated Nitrones with Chiral 3-Propioloyloxazolidin-2-Ones, COA of Formula: C4H7NO2, the main research area is oxazonine preparation diastereoselective; vinyl unsaturated nitrone propioloyloxazolidinone tandem cycloaddition rearrangement silver catalyst.
A variety of chiral nine-membered N-heterocycles were prepared in moderate to good yields with high diastereoselectivity through a silver(I)-catalyzed [3+2] cycloaddition and [3,3]-rearrangement of N-vinyl-α, β-unsaturated nitrones and chiral 3-propioloyloxazolidin-2-ones. Exptl. studies showed that silver catalyst promoted the cycloaddition and rearrangement process, and the stereochem. of the nine-membered N-heterocycles was controlled via [3,3]-rearrangement by chiral oxazolidinone-auxiliary through a boat-like transition state. Moreover, the obtained nine-membered N-heterocycle diastereomers were converted to chiral pyrrolizines with high diastereoselectivity and pyrrolizine carboxylate was obtained in 54% yield with 90% ee by the removal of chiral auxiliary.
Advanced Synthesis & Catalysis published new progress about [3+2] Cycloaddition reaction, stereoselective. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, COA of Formula: C4H7NO2.
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem