Safety of Ethyl 3-bromo-2-oxopropanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Fe3O4 MNPs as a green catalyst for syntheses of functionalized [1,3]-oxazole and 1H-pyrrolo-[1,3]-oxazole derivatives and evaluation of their antioxidant activity.
Iron oxide magnetic nanoparticles (Fe3O4MNPs) were synthesized in a green biosynthetic manner using aqueous extract of clover leaves. Fe3O4MNPs were applied as a magnetically separable nanocatalyst for the green syntheses of functionalized [1,3]-oxazoles I [R = COOEt, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4] and 1H-pyrrolo-[1,3]-oxazoles II [R1 = COOEt, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4; R2 = Me, Et; R3 = COOEt, 4-MeC6H4, 4-MeOC6H4] as promising antioxidant compounds in excellent yields at 50° and room temperature, resp. The antioxidant activities of the most stable compounds I [R = 4-MeOC6H4, 4-O2NC6H4] and 1H-pyrrolo-[1,3]-oxazoles II [R1 = R3 = COOEt, 4-MeOC6H4; R2 = Me] were evaluated by both 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reduction activity potential assays. Compound I [R = 4-MeOC6H4] was shown a remarkable radical scavenging activity, and II [R1 = R3 = CO2Et, R2 = Me] was shown very good reducing activity relative to standards (BHT and TBHQ).
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem