Metal-free stereoselective addition of propiolic acids to ynamides: a concise synthetic route to highly substituted enediyne/dienyne-(E)-N,O-acetals was written by Prasad, Rangu;Kanikarapu, Suresh;Dutta, Shubham;Vangara, Srinivas;Sahoo, Akhila K.. And the article was included in New Journal of Chemistry in 2022.Category: oxazolidine This article mentions the following:
A straightforward and sustainable approach for the 1,2-addition of propiolic acids to ynamide has led to bench-stable sp2 (E)-enol-enamides of enediynes and dienynes. The reaction is chemo-, regio- and stereoselective and did not require metal catalysts and solvent. The ynamide motif is extremely amenable to functionalization in the presence of the tethered alkyne triple bond. The synthetic technique is operationally simple; no hydrolysis of ketenimine species occurs under acidic conditions. The transformation tolerates a wide range of common functional groups, constructing a library of highly functionalized 1,5,5’/6′-enediynes and 1,5,5′-dienynes of sp2 (E)-N,O-acetal skeletons. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Category: oxazolidine).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Category: oxazolidine
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem