A chiral phosphonoamide ester compound and the preparation method thereof was written by Luo, Mei. And the patent was published on March 21,2012.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:
This patent supplies a chiral phosphonoamide ester compound, which is named 4H-1,3,2-phenyloxazolinyl phosphonoamide-2,3-dihydro-2-phenyl-3(R)-(R)-α-(chloromethyl)-2-oxide, in which R is selected form -CH2CH(CH3)2 or -Ph or -CH2Ph. The preparation method comprises reacting 2-cyanophenol and D-amino alc. in the presence of ZnCl2 under water and oxygen free condition in chlorobenzene under reflux for 24 h, reacting the obtained intermediate in mixture of benzene and pyridine under water and oxygen free condition and under reflux for 15 h to obtain title product. Title product is used as chiral catalyst, and has high catalytic activity and high selectivity. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).
(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem