Chiral phosphoramidate compound used as chiral catalyst was written by Luo, Mei. And the patent was published on May 25,2011.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:
The invention relates to chiral phosphoramidate compound as shown in formula I, wherein R is -CH2CH(CH3)2 or -CH(CH3)2 or -CH2Ph. Title chiral phosphoramidate compound is prepared by allowing to react 2-cyanophenol with L-amino alc. in chlorobenzene solvent for 24 h under water-free and oxygen-free conditions and refluxing in the presence of anhydrous ZnCl2 as catalyst to obtain 2-[(4S)-4,5-dihydro-4-R-2-oxazolinyl]phenol intermediate, then reacting with phenylphosphonyl dichloride in toluene-triethylamine solvent under refluxing for 24 h. The inventive product can be used as chiral catalyst, showing fine catalytic activity and high enantioselectivity in asym. cyanosilylation of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).
(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem