Chiral phosphonic acid ester and its synthesis method was written by Luo, Mei. And the patent was published on December 2,2009.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:
The invention relates to a chiral phosphonic acid ester, diphenylphosphonic acid-2-[(4S)-4,5-dihydro-4-R-2-oxazolinyl]phenol ester I, wherein R is -CH2CH(CH3)2, -CH(CH3)2, -Ph or -CH2ph. The method for synthesis of the chiral phosphonic acid ester comprises reacting 2-cyanophenol with L-amino alc. in water-free and oxygen-free condition in the presence of anhydrous ZnCl2 in chlorobenzene under reflux for 24 h to obtain intermediate, reacting with diphenylphosphinyl chloride in water-free and oxygen-free condition in toluene-triethylamine solvent under reflux for 24 h, isolating and purifying. The chiral phosphonic acid ester can react with metal organic compound to form complex, which exhibits high catalytic activity and high enantiomorphous selectivity in asym. synthesis of amygdalic acid. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).
(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem