Chiral phosphine compound, its synthesis method and application was written by Luo, Mei. And the patent was published on September 23,2009.Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:
The invention provides a method for the synthesis of chiral phosphine compounds of formula I (R = iso-Bu, iso-Pr, Ph, and benzyl), which comprises allowing to react 2-cyanophenol with L-amino alc. in the presence of anhydrous Compounds of formula I were prepared via cyclization of 2-cyanophenol with L-amino alcs.; the resulting (oxazolinyl)phenols underwent condensation with phenylphosphonic dichloride to give I. The L-amino alcs. are selected from L-leucinol, L-valinol, L-Ph glycinol, and L-Ph alaninol. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).
(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem