On November 5, 2010, Ohtani, Takashi; Tsukamoto, Shinya; Kanda, Hiroshi; Misawa, Kensuke; Urakawa, Yoshifumi; Fujimaki, Takahiro; Imoto, Masaya; Takahashi, Yoshikazu; Takahashi, Daisuke; Toshima, Kazunobu published an article.Application of 168297-86-7 The title of the article was Total Synthesis of Incednam, the Aglycon of Incednine. And the article contained the following:
The first total synthesis of incednam I (R = H), the aglycon of the macrolactam antibiotic incednine I (R = II), is described. Incednine has been reported to exhibit significant inhibitory activity against the antiapoptotic oncoproteins Bcl-2 and Bcl-xL. The synthesis of I (R = H) commenced with the preparation of the C1-C13 subunit III and the C14-C23 subunit IV. The construction of the novel 24-membered macrocycle was achieved by the application of a Stille coupling between III and IV, followed by macrolactamization. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application of 168297-86-7
The Article related to incednam incednine aglycon preparation stille coupling macrolactamization, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application of 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem