Chemistry, like all the natural sciences, Name: (R)-4-Phenyloxazolidin-2-one, begins with the direct observation of nature¡ª in this case, of matter.90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a document, author is Lu, Bohua, introduce the new discover.
Enantioselective Conjugate Addition-Protonation of 5H-Oxazol-4-ones and 5-Methylene 1,3-Oxazolidine-2,4-diones: 2,2′-Biphenol-Induced Diastereoselectivity Switch
of main observation and conclusion A synthetic strategy for catalytic asymmetric conjugate addition-protonation and diastereoselective switch between 5H-oxazol-4-ones and 5-methylene 1,3-oxazolidine-2,4-diones was established. An array of chiral conjugate addition-protonation products bearing 1,3-O-heterotertiary-O-heteroquarternary nonadjacent stereocenters were obtained in excellent yields, moderate to good diastereoselectivities, and excellent enantioselectivities (up to 97% yield, 11: 1 dr, and 98% ee). Induction by 2,2′-biphenol could effectively promote the production of the corresponding diastereoisomers via cycloaddition intermedia.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 90319-52-1. Name: (R)-4-Phenyloxazolidin-2-one.
Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem