So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Zhen; Wang, Zhen; Chekshin, Nikita; Qian, Shaoqun; Qiao, Jennifer X.; Cheng, Peter T.; Yeung, Kap-Sun; Ewing, William R.; Yu, Jin-Quan researched the compound: 2-Chloro-5-hydroxyisonicotinic acid( cas:1060804-57-0 ).Safety of 2-Chloro-5-hydroxyisonicotinic acid.They published the article 《A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen》 about this compound( cas:1060804-57-0 ) in Science (Washington, DC, United States). Keywords: tautomeric ligand palladium regioselective hydroxylation mol oxygen. We’ll tell you more about this compound (cas:1060804-57-0).
Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. IR, x-ray, and computational anal. support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.
Although many compounds look similar to this compound(1060804-57-0)Safety of 2-Chloro-5-hydroxyisonicotinic acid, numerous studies have shown that this compound(SMILES:O=C(O)C1=C(O)C=NC(Cl)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem