Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. Synthetic Route of 102029-44-7. Introducing a new discovery about 102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone
We report a concise asymmetric synthesis of rakicidin A, a macrocyclic depsipeptide that selectively inhibits the growth of hypoxic cancer cells and stem-like leukemia cells. Key transformations include a diastereoselective organocatalytic cross-aldol reaction to build the polyketide portion of the molecule, a highly hindered ester fragment coupling reaction, an efficient Helquist-type Horner – Wadsworth – Emmons (HWE) macrocyclization, and a new DSC-mediated elimination reaction to construct the sensitive APD portion of rakicidin A. We further report the preparation of a simplified structural analogue (WY1) with dramatically enhanced hypoxia-selective activity. Take my breath away: Rakicidin A, a depsipeptide natural product with hypoxia-selective antitumour activity, is comprised of a ring system containing sensitive and congested functionalities. A modular asymmetric synthesis and initial biological evaluation of the natural product, and the discovery of a simplified analogue displaying strongly enhanced hypoxia selectivity is reported.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 102029-44-7 is helpful to your research. Synthetic Route of 102029-44-7
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2057NO – PubChem