With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
In anhydrous and oxygen-free environment, 36g of 4-[2-(4-fluoro-phenyl)-[1,3]dithiacyclolan-2-yl]-butyric acid (IV) was added and 300ml of dichloromethane was added. ,Add 50ml triethylamine, temperature -20C-10C,A mixture of 20 ml of pivaloyl chloride + 50 ml of tetrahydrofuran is added dropwise.Reaction for 2 hours. Add 6.4g of anhydrous lithium chloride and stir for 2 hours.27g 4-phenyl-2-oxazolidone added,The reaction mixture was stirred for 5-7 h, and extracted and crystallized to obtain Intermediate VI.Yield 96.1%., 99395-88-7
As the paragraph descriping shows that 99395-88-7 is playing an increasingly important role.
Reference£º
Patent; Shandong New Age Pharmaceutical Co., Ltd.; Zhang Guimin; Zang Chao; Xia Mingjun; (14 pag.)CN107488165; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem