With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90719-32-7,(S)-4-Benzyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
90719-32-7, EXAMPLE 5; Preparation of (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, compound; 4-Dimethylaminopyridine (2.55 g, 21 .3 mmol) and triethylamine (46.9 ml, 340.8 mmol) in dichloromethane (100 ml) are added to a solution of (S)-(-)-4- benzyl-2-oxazolidinone (37.7g, 213 mmol) in dichloromethane (300 ml). Next, isovaleroyi chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) is added to the previously prepared mixture and cooled to 0 C keeping the internal temperature below 10 C. The reaction mixture is stirred for 30 minutes at 10 C, then the formed salts are filtered. Water (100 ml) is added and the phases are separated. The organic phase is washed with water (100 ml) and brine (100 ml), dried over sodium sulphate and evaporated to dryness obtaining 53 g of a yellow oil, which solidifies over time (yield 95%).1 H NMR (300 MHz, CDCI3, 298K) delta 7.35-7.15 (m, 5H), 4.71 -4.61 (m, 1 H), 4.21 – 4.10 (m, 2H), 3.35-3.25 (dd, J = 13.2, J = 3.4 Hz.1 H), 2.85-2.72 (dd, J = 14.97 Hz, 6.8 Hz, 1 H), 2.80-2.67 (m, 2H), 2.29-2.12 (sept, J=13.2 Hz.1 H), 1 .03-0.98 (d, J = 6.8 Hz.3H), 0.98-0.95 (d, J = 6.8 Hz, 3H).13C NMR (75 MHz, CDCI3, 298K) delta 175.6, 171 .2, 154.4, 137.1 , 130.5, 130.2, 126.0, 82.1 , 66.1 , 45.6, 42.6, 41 .4, 34.0, 28.7, 27.3, 19.7.
As the paragraph descriping shows that 90719-32-7 is playing an increasingly important role.
Reference£º
Patent; CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo; WO2011/151442; (2011); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem