With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
695-53-4, To a solution of 150mg (0.488mol) of the compound obtained in the Example 122 in 5mL of tetrahydrofuran were added 75.6mg (0.586mmol) of 5,5-dimethyloxazolidine-dione, 154mg (0.586mmol) of triphenylphsophine and 267muL (0.586mmol) of diethyl azodicarboxylate (40% toluene solution), and the mixture was stirred for 2 hours at room temperature. After the reaction, water was added to the reaction mixture and the mixture was extracted with dichloromethane. The organic layer was dried over with anhydrous sodium sulfate and the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/acetone = 2/1 for first trial, and hexane/ethyl acetate = 2/1 for second trial) to give 133mg (65%) of the title compound.
As the paragraph descriping shows that 695-53-4 is playing an increasingly important role.
Reference£º
Patent; Daiichi Asubio Pharma Co., Ltd.; EP1775298; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem