With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.
497-25-6, General procedure: Alkynylation of gamma-Lactam and Oxazolidin-2-ones with CopperAcetylide; Procedure 2A 5 mL round-bottomed flask was successively charged with the nitrogennucleophile 3 (8.0 mmol), the copper acetylide 2 (2.0 mmol),and MeCN (4 mL). The resulting bright yellow slurry was thentreated with TMEDA (300 muL, 2.0 mmol) and the reaction mixturewas vigorously stirred at r.t. and under an atmosphere of O2 (balloon).After complete disappearance of the alkynylcopper reagent(complete dissolution to a deep blue homogeneous reaction mixture:typically 24-48 h), the crude reaction mixture was concentratedunder vacuum, and the residue was finally purified by flashchromatography over silica gel to afford the desired ynamide 4.
As the paragraph descriping shows that 497-25-6 is playing an increasingly important role.
Reference£º
Article; Theunissen, Cedric; Lecomte, Morgan; Jouvin, Kevin; Laouiti, Anouar; Guissart, Celine; Heimburger, Jeremy; Loire, Estelle; Evano, Gwilherm; Synthesis; vol. 46; 9; (2014); p. 1157 – 1166;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem