With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.,497-25-6
[0528] General Procedure for Goldberg Reaction [0529] This protocol was performed according to conditions disclosed in Org. Lett. 2003, 5 (7), 963. [0530] To a suspension of copper(I) iodide (0.354 g, 1.86 mmol), potassium carbonate (7.35 g, 53.2 mmol) and (¡À)-trans-1,2-diaminocyclohexane (0.328 ml, 2.67 mmol) in dioxane, (15 ml) 9 (5 g, 26.7 mmol) and 10b (2.352 g, 27.01 mmol) were added and the reaction mixture was stirred at 100 C. for 20 h. Reaction mixture was cooled and filtered through silica gel pad with the help of EtOAc (150 ml). Filtrate was concentrated in vacuo to 11b 4.7 g (91%) [0531] Analogous coupling reactions performed according to the above procedure and utilising the appropriate coupling partners according to the schemes gave the following yields: 11a (81%), 11c (40%), 11d (55%), 24a (74%), 24b (64%) [0532] *The above reaction also works under the microwave conditions at 110 C. in 4 h to give 11 (50-90%).
As the paragraph descriping shows that 497-25-6 is playing an increasingly important role.
Reference£º
Patent; Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David; US2013/53372; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem