With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.
1) Mix 2-oxazolidinone and sodium hydride in a molar ratio of 1: 1, and add N, N-dimethylformamide to dissolve thoroughly,propargyl bromide (the molar ratio of propargyl bromide to 2-oxazolidinone is 1: 1) is added dropwise to the above reaction solution,The reaction was stirred at room temperature for 0.5 and then quenched with water. The organic layer was extracted with ethyl acetate.After drying and concentration, column chromatography (eluent system: petroleum ether: ethyl acetate = 1: 1) to obtain a compound of the general formula II-1;
As the paragraph descriping shows that 497-25-6 is playing an increasingly important role.
Reference£º
Patent; Chongqing University; Xia Yi; Zhang Yanhua; Liu Qian; Lin Yun; (25 pag.)CN110590686; (2019); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem