With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.
Sodium hydride (60% dispersion in oil 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 [ML)] under nitrogen and the mixture was stirred for 15 min at 5 [C.] A solution of 6-bromohexyl [4- (3-IODOPHENYL) BUTYL] ether (10.7 g) in DMF (30 ml) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried [(NA2SO4)] and evaporated. The residue was purified on biotage (90 g cartridge) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.
As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/22547; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem