With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
A mixture of (2E)-3- [5- (4-fluorophenyl)-l-methyl-lH- PYRAZOL-4-YL]-N- [4- (HYDROXYMETHYL) phenyl] acrylamide (8.4 g), thionyl chloride (2.59 mL) and tetrahydrofuran (70 mL) was heated under reflux for 3 hrs. The reaction mixture was poured into saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then saturated brine, dried (MGSO4) and concentrated to give a solid (6.22 g). To a mixture of 1, 3-oxazolidine-2,4-dione (123.3 mg) and N, N- dimethylformamide (5 mL) was added sodium hydride (60% in oil, 48.8 mg) and the mixture was stirred at room temperature for 30 min. The obtained solid (300 mg) was added to the reaction mixture and the mixture was further stirred overnight at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with 0. 1N hydrochloric acid, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was recrystallized from ethyl acetate-hexane to give (2E)-N-14- [ (2, 4-DIOXO-1, 3-oxazolidin-3- yl) METHYL] PHENYL}-3- [5- (4-FLUOROPHENYL)-1-METHYL-LH-PYRAZOL-4- yl] acrylamide as yellow prism crystals (132 mg, yield 37%). melting point: 239-240C.
2346-26-1, As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.
Reference£º
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/39365; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem