With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1676-86-4,(S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate,as a common compound, the synthetic route is as follows.
1676-86-4, The affinity peptides (obtained from SynPep Corporation, Dublin, Calif.) were dried under vacuum. A dried 40 mL glass vial fitted with a silicone rubber septum and magnetic stirring bar was charged with 15 mL of dry DMF. The dried, affinity peptide, as indicated in Table 1, was added to the vial and the contents were stirred until the peptide was completely dissolved. The vial was then placed into a heated aluminum block with stirring and the contents were allowed to equilibrate to a temperature of 50 C. Then, epsilon-carbobenzyloxylysine N-carboxyanhydride (CbzLys), prepared as described above, was added as a 1 mmol/mL solution in dry DMF, as shown in Table 1, and the contents were allowed to stir for 4 h. The remaining epsilon-carbobenzyloxylysine N-carboxyanhydride, also in DMF, was injected, as shown in Table 1, and the reactants were allowed to stir at 50 C. for 72 h. The product was collected by evaporating the solvent, washing with hexanes, and then drying in vacuum. Samples of the product were analyzed using MALDI mass spectrometry to confirm the presence of the desired product. The results of the analysis are given in Table 2.
As the paragraph descriping shows that 1676-86-4 is playing an increasingly important role.
Reference£º
Patent; O’Brien, John P.; US2007/22547; (2007); A1;,
Oxazolidine – Wikipedia
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