With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.
General procedure: Following the general procedure, the reactionwas carried out starting from carboxylic acid 5 (735 mg, 3 mmol), EDC (630 mg, 3.1 mmol), HOBT (504 mg, 1.1mmol), 1-pentadecyne (1.872 g, 9 mmol) and n-butyllithium(576 mg, 9 mmol), to give 783 mg of ynone 7as an oil (60% yield). TLC (Hexane-AcOEt 85:15) RF 0.50. [a]D-51.9(c 2.0 in CHCl3). 1H NMR(300 MHz, CDCl3): d 4.34(dd, 1H, J = 7.4,3.8 Hz) 4.14 (dd, 1H, J =9.4, 7.4 Hz), 4.05 (dd, 1H, J =9.4, 3.8 Hz), 2.37 (t, 2H, J = 6.9), 1.69 (s, 3H), 1.53 (s, 3H), 1.49 (m, 4H), 1.45 (s, 9H),1.24 (m, 18H), 0.87 (t, 3H, J = 7.2Hz). 13CNMR (75 MHz, CDCl3): delta 186.2, 127.9, 98.1, 95.3,80.6, 66.5, 65.7, 65.3, 51.6, 31.8, 29.5, 29.4, 29.3, 28.9, 28.8, 28.3, 28.1,27.5, 26.1, 25.1, 25, 24.2, 22.6, 19, 14. Anal.Calcd. For C26H45NO4: C, 71.68; H, 10.41; N,3.22. Found: C, 71.66; H, 10.40; N, 3.21
139009-66-8, As the paragraph descriping shows that 139009-66-8 is playing an increasingly important role.
Reference£º
Article; Morales-Serna, Jose Antonio; Sauza, Alejandro; Padron De Jesus, Gabriela; Gavino, Ruben; Garcia De La Mora, Gustavo; Cardenas, Jorge; Tetrahedron Letters; vol. 54; 52; (2013); p. 7111 – 7114;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem