With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133812-16-5,(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.
Method two: replace the nitrogen reaction bottle,24.5 g (0.1 mol) of intermediate (I) and 400 ml of anhydrous dichloromethane are added and the temperature is lowered to -50C to -60C,120 ml (0.12 mol) of a 1 M solution of titanium tetrachloride in dichloromethane are slowly added dropwise.Then 46.3 ml (0.24 mol) of N,N-tetramethylethylenediamine and 19.4 ml (0.2 mol) of N-methylpyrrolidone are added dropwise,The stirring was completed for 30 minutes.A solution of 19.5 g (0.2 mol) of 2,5-difluorobenzaldehyde in 70 ml of dichloromethane was slowly added dropwise and stirred for 2 h.The reaction temperature was slowly raised to 15C.TLC showed that the reaction was complete, add saturated ammonium chloride, filter, separate the organic layer, and wash with saturated sodium bicarbonate.After drying and silica gel column chromatography, 34.8 g of intermediate (II) was isolated with a yield of 90%.
As the paragraph descriping shows that 133812-16-5 is playing an increasingly important role.
Reference£º
Patent; Zhong Guifa; Wu Yiwu; Lan Xiaobing; (12 pag.)CN107459501; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem