With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131685-53-5,(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.
General procedure: To a solution of imide 11 (548 mg, 2.35 mmol) in CH2Cl2 (11.8 mL) was added dropwise a solution of TiCl4 in CH2Cl2 (1.00M, 3.53 mL, 3.53 mmol) at 0 C. The color of the solution turned to yellow soon. After stirring for 5 min, TMEDA (0.928 mL, 6.23 mmol) was added dropwise. The resulting dark red solution was stirred for 1 h at 0 C before n-octanal (12,0.819 mL, 5.24mmol) was added dropwise. After the resulting mixture was stirred for another 2 h at 0 C, the reaction was quenched with aqueous NH4Cl. The resulting yellow precipitates were filtered off. The filtrate was extracted threetimes with CH2Cl2. The combined organic phases were dried over Na2SO4 and concentrated under reduced pressure.The crude product was purified by silica gel column chromatography (diethyl ether / n-hexane 1:3 to 1:1) to give 13(575 mg, 1.59 mmol, 68%) as a pale yellow oil.
131685-53-5, As the paragraph descriping shows that 131685-53-5 is playing an increasingly important role.
Reference£º
Article; Nakajima, Daisuke; Sueyoshi, Kosuke; Orihara, Kensuke; Teruya, Toshiaki; Yokoshima, Satoshi; Synlett; vol. 30; 8; (2019); p. 924 – 927;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem