An, Seungchan; Kim, Gyudong; Kim, Hyun Jin; Ahn, Sungjin; Kim, Hyun Young; Ko, Hyejin; Hyun, Young Eum; Nguyen, Mai; Jeong, Juri; Liu, Zijing; Han, Jinhe; Choi, Hongseok; Yu, Jinha; Kim, Ji Won; Lee, Hyuk Woo; Jacobson, Kenneth A.; Cho, Won Jea; Kim, Young-Mi; Kang, Keon Wook; Noh, Minsoo; Jeong, Lak Shin published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).Formula: C5H2Cl2N4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.
Following our report that A3 adenosine receptor (AR) antagonist 1 exhibited a polypharmacol. profile as a dual modulator of peroxisome proliferator-activated receptor (PPAR)γ/δ, we discovered a new template, 1′-homologated adenosine analogs 4a-4t, as dual PPARγ/δ modulators without AR binding. Removal of binding affinity to A3AR was achieved by 1′-homologation, and PPARγ/δ dual modulation was derived from the structural similarity between the target nucleosides and PPAR modulator drug, rosiglitazone. All the final nucleosides were devoid of AR-binding affinity and exhibited high binding affinities to PPARγ/δ but lacked PPARα binding. 2-Cl derivatives exhibited dual receptor-binding affinity to PPARγ/δ, which was absent for the corresponding 2-H derivatives 2-Propynyl substitution prevented PPARδ-binding affinity but preserved PPARγ affinity, indicating that the C2 position defines a pharmacophore for selective PPARγ ligand designs. PPARγ/δ dual modulators functioning as both PPARγ partial agonists and PPARδ antagonists promoted adiponectin production, suggesting their therapeutic potential against hypoadiponectinemia-associated cancer and metabolic diseases.
Here is just a brief introduction to this compound(5451-40-1)Formula: C5H2Cl2N4, more information about the compound(2,6-Dichloropurine) is in the article, you can click the link below.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem