Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Reaction kinetics and process optimization for nitration of 2-methyl-4,6-dihydroxy-pyrimidine.
1,1-Diamino-2,2-dinitroethene (FOX-7) is a thermally stable insensitive high explosive. Fox-7 is synthesized by nitration of 2-methyl-4,6-dihydroxy-pyrimidine (MDP). Nitration of MDP is a low temperature and highly exothermic reaction. Adiabatic rise in temperature of this nitration reaction is very high (> 220°) which indicates that the conduct of reactions at lowest possible optimum temperature is safer and favorable. In order to optimize the reaction time without compromising yield, the reaction kinetics were studied at three different temperatures (5, 15, and 25°) using differential method. The effect of temperature on yield (%) of FOX-7 was also studied at two more addnl. temperatures, 35 & 42°. Since the nitration of MDP is sensitive to temperature, rate of reaction was studied at fixed temperature with the variation of time keeping all the other parameters constant In the present studies, it is found that optimum temperature of nitration is 15° and rate of reaction follows pseudo second order with a rate constant 0.0338 (min-1) (concentration-1). The reaction time evaluated for 85% conversion is around 1.8 h at 15° based on the kinetics, which resembles to calorimetric studies too. Activation energy of MDP nitration is found to be 42 kJ/mol, using reaction kinetic data based on temperature dependent rate equation derived from the Arrhenius’s law. Heat generation rate increases with the increase of reaction temperature
In addition to the literature in the link below, there is a lot of literature about this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, illustrating the importance and wide applicability of this compound(1194-22-5).
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem