452339-73-0, Name is (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. COA of Formula: C13H15NO4In an article, once mentioned the new application about 452339-73-0.
The discovery of long-acting saligenin beta2 adrenergic receptor agonists incorporating a urea group
A series of novel, potent and selective human beta2 adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and also in vivo similar to that of salmeterol. It had lower oral absorption and bioavailability than salmeterol in both rat and dog. It had a turnover ratio similar to salmeterol, with no evidence for formation of any aniline metabolites in human liver microsomes and hepatocytes. However no crystalline salts suitable for inhaled delivery were identified.
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2447NO – PubChem