Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory was written by Mata, Dani C.;Davis, John F.. And the article was included in Forensic Science International in 2022.Related Products of 1665-48-1 This article mentions the following:
A novel forensic method was developed to quantitate 39 drugs of toxicol. interest for ante-mortem and postmortem anal. This method was created to combine and replace four existing quantitation methods as well as add three addnl. compounds of interest and serves to drastically increase the efficiency of the criminalists and reduce the case backlog. The method is currently applied to ante-mortem blood, postmortem blood, urine, liver, brain, and gastric contents. The extraction was performed by using a protein precipitation and DPX WAX-S tips with anal. on a Waters i-class Acquity ultra-performance liquid chromatog. with a Phenomenex Kinetex Column (1.7μm Biphenyl Å, 2.1 x100 mm) followed by a Waters XeVo-TQS tandem mass spectrometer using pos. electrospray ionization in multiple reaction monitor mode. The sample volume required for anal. was 0.5 mL, or 0.5 g, an improvement from 4 mL when performing previous methods utilized in the laboratory The improved method incorporated the 2017 recommended cut-offs for toxicol. investigation of driving under the influence of drugs and was validated following the SWGTOX and ANSI/ASB guidelines of method validation. The advantages of analyzing low volume cases and/or detecting drugs previously outside the laboratorys scope of anal., (such as gabapentin, pregabalin and baclofen) will be presented in two case studies. The multi-drug quantitation method allowed for the anal. of 39 drugs including a hydrolysis step, if needed, with only 0.5 mL or 0.5 g of sample. The method condensed two previously un-validated quant. methods and two addnl. qual. methods, which detected many commonly seen drugs, all into a single method. Three addnl. analytes of interest, gabapentin, pregabalin and baclofen, which it had previously been unable to detect, were added to the new method. The added benefit of these new drugs added both the coroners investigators in cause of death determination and driving under the influence of drugs investigation especially with the high prevalence of gabapentin. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Related Products of 1665-48-1).
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Related Products of 1665-48-1
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem