Computed Properties of C5H7BrO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones. Author is Kokuev, Aleksandr O.; Ioffe, Sema L.; Sukhorukov, Alexey Yu..
Michael addition of malonic esters to azoalkenes, generated in situ from α-bromo- and α-chlorohydrazones, has been accomplished. Both aliphatic and aromatic substrates bearing different functional groups were tolerated. The use of a strong base (sodium hydride) for generation of azoalkenes and deprotonation of malonate was found to be essential for a successful coupling. Synthetic potential of the obtained β-hydrazonoalkylmalonates RNHN:C(R1)CH2CH(CO2R2)2 [R = Ac, Boc, Cbz, 2,4-(O2N)2C6H3; R1 = t-Bu, EtO2C, Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, PhCH2] was demonstrated by their smooth conversion into five- and six-membered N-heterocycles, functionalized hydrazides, 2-(2-oxo-2-arylethyl)malonates and 2-arylethylmalonates.
《Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Computed Properties of C5H7BrO3.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem