Inhibition of TLR1/2 dimerization by enantiomers of metal complexes was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 135948-04-8 The following contents are mentioned in the article:
The authors report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To the knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Related Products of 135948-04-8).
(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 135948-04-8
135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8