Quality Control of Oxazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents. Author is Banzragchgarav, Orkhon; Ariefta, Nanang R.; Murata, Toshihiro; Myagmarsuren, Punsantsogvoo; Battsetseg, Badgar; Battur, Banzragch; Batkhuu, Javzan; Nishikawa, Yoshifumi.
179 Compounds in a Mongolian compound library were investigated for their inhibitory effect on the in vitro growth of Plasmodium falciparum and Toxoplasma gondii. Among these compounds, brachangobinan A at a half-maximal inhibition concentration (IC50) of 2.62μM and a selectivity index (SI) of 27.91; 2-(2-hydroxy-5-O-methylphenyl)-5-(2,5-dihydroxyphenyl)oxazole (IC50 3.58μM and SI 24.66); chrysosplenetin (IC50 3.78μM and SI 15.26); 4,11-di-O-galloylbergenin (IC50 3.87μM and SI 13.38); and 2-(2,5-dihydroxyphenyl)-5-(2-hydroxyphenyl)oxazole (IC50 6.94μM and SI 11.48) were identified as potential inhibitors of P. falciparum multiplication. Addnl., tricin (IC50 12.94μM and SI > 23.40) was identified as a potential inhibitor of T. gondii multiplication. Our findings represent a good starting point for developing novel antimalarial and anti-Toxoplasma therapeutics from Mongolian compounds
Different reactions of this compound(Oxazole)Quality Control of Oxazole require different conditions, so the reaction conditions are very important.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem