Li, Minyong published the artcileStructure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi, Product Details of C9H6BrNO, the publication is ChemMedChem (2008), 3(8), 1242-1249, database is CAplus and MEDLINE.
Quorum sensing has been implicated in the control of pathol. relevant bacterial behavior such as secretion of virulence factors, biofilm formation, sporulation, and swarming motility. The Al-2 quorum sensing pathway is found in both Gram-pos. and Gram-neg. bacteria. Therefore, antagonizing Al-2 quorum sensing is a possible approach to modifying bacterial behavior. However, efforts in developing inhibitors of Al-2-mediated quorum sensing are especially lacking. High-throughput virtual screening using the V. harveyi LuxP crystal structure identified two compounds that were found to antagonize Al-2-mediated quorum sensing in V. harveyi without cytotoxicity. The sulfone functionality of these inhibitors was identified as critical to their ability to mimic the natural ligand in their interactions with Arg215 and Arg310 of the active site.
ChemMedChem published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.
Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem