Easy-to-Implement Hydrogen Isotope Exchange for the Labeling of N-Heterocycles, Alkylkamines, Benzylic Scaffolds, and Pharmaceuticals was written by Levernier, Etienne;Tatoueix, Kevin;Garcia-Argote, Sebastien;Pfeifer, Viktor;Kiesling, Ralf;Gravel, Edmond;Feuillastre, Sophie;Pieters, Gregory. And the article was included in JACS Au in 2022.Recommanded Product: 139264-17-8 This article mentions the following:
Facilitating access to deuterated and tritiated complex mols. is of paramount importance due to the fundamental role of isotopically labeled compounds in drug discovery and development. Deuterated analogs of drugs are extensively used as internal standards for quantification purposes or as active pharmaceutical ingredients, whereas tritiated drugs are mandatory for preclin. ADME studies. In this report, we describe the labeling of prevalent substructures in FDA-approved drugs such as azines, indoles, alkylamine moieties or benzylic carbons by the in situ generation of Rh nanoparticles able to catalyze both C(sp2)-H and C(sp3)-H activation processes. In this easy-to-implement labeling process, Rh nanocatalysts are formed by decomposition of a com. available rhodium dimer under a deuterium or tritium gas atm. (1 bar or less), using the substrate itself as a surface ligand to control the aggregation state of the resulting metallic clusters. It is noteworthy that the size of the nanoparticles observed is surprisingly independent of the substrate used and homogeneous, as evidenced by transmission electron microscopy experiments This method has been successfully applied to the one-step synthesis of: (1) deuterated pharmaceuticals useable as internal standards for MS quantification: (2) tritiated drug analogs with very high molar activities (up to 113 Ci/mmol). In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Recommanded Product: 139264-17-8).
(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Recommanded Product: 139264-17-8
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem