On December 3, 2020, Koehler, Michael Friedrich Thomas; Smith, Peter Andrew; Winter, Dana; Sow, Boubacar; Sturino, Claudio; Pelletier, Guillaume; Boudreault, Jonathan published a patent.Application of 97859-49-9 The title of the patent was Preparation of macrocyclic broad spectrum antibiotics. And the patent contained the following:
Macrocyclic compounds of formula I [R1 = H, alkyl; R2 = H, (substituted) NH2, alkyl, etc.; R3 = H, cycloalkyl, alkyl, etc.; R4 = H, alkyl; X = alkylene, arylene, etc.; Y = bond, O, S, alkylene, arylene, etc.; Z = H, halo, CN, alkoxy, alkylthio, acyl, alkyl, aryl, etc.] are prepared as antibacterial agents which have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided. Thus, II was prepared, and had serum MIC value of 0.5μM against E. coli 25922. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Application of 97859-49-9
The Article related to macrocycle preparation antibacterial, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application of 97859-49-9
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem