Khan, Anwar Arfien Md. published the artcilePositive and negative modulation of Bombyx mori adenylate cyclase by 5-phenyloxazoles: identification of Octopamine and tyramine receptor agonists, Name: 5-(4-Bromophenyl)oxazole, the publication is Archives of Insect Biochemistry and Physiology (2003), 52(1), 7-16, database is CAplus and MEDLINE.
Nineteen 5-phenyloxazoles (5POs) were examined for their ability to modulate adenylate cyclase by measuring cAMP produced in head membrane homogenates of fifth instar larvae of the silkworm Bombyx mori. Among the compounds tested, 5-(4-methoxyphenyl)oxazole and the 2,6-dichlorophenyl congener showed the highest activation of adenylate cyclase; both compounds produced approx. half the level of cAMP produced by the action of octopamine (OCT). The OCT receptor antagonists chlorpromazine, mianserin, and metoclopramide attenuated 9-stimulated cAMP production In contrast, 5-(4-hydroxyphenyl)oxazole and the 4-cyanophenyl congener attenuated both OCT-stimulated and basal cAMP production The tyramine (TYR) receptor antagonist yohimbine inhibited the neg. effect of 8. These findings indicate that the 5PO class of compounds includes both pos. and neg. modulators of adenylate cyclase in the heads of B. mori larvae, and that 9 and 8 are OCT and TYR receptor agonists, resp. These compounds might prove useful for a pharmacol. dissection of biogenic amine receptors.
Archives of Insect Biochemistry and Physiology published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Name: 5-(4-Bromophenyl)oxazole.
Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem