Lithium Amino Alkoxide-Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol was written by Jermaks, Janis;Tallmadge, Evan H.;Keresztes, Ivan;Collum, David B.. And the article was included in Journal of the American Chemical Society in 2018.Computed Properties of C9H15NO3 This article mentions the following:
Building on structural and mechanistic studies of lithiated enolates derived from acylated oxazolidinones (Evans enolates) and chiral lithiated amino alkoxides, we found that amino alkoxides amplify the enantioselectivity of aldol additions The pairing of enantiomeric series affords matched and mismatched stereoselectivities. The structures of mixed tetramers showing 2:2 and 3:1 (alkoxide-rich) stoichiometries are determined spectroscopically. Rate and computational studies provide a viable mechanistic and stereochem. model based on the direct reaction of the 3:1 mixed tetramers, but they raise unanswered questions for the 2:2 mixed aggregates. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0Computed Properties of C9H15NO3).
(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Computed Properties of C9H15NO3
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem