Engineering bio-inspired peptide-polyurea hybrids with thermo-responsive shape memory behavior was written by Jang, Daseul;Thompson, Chase B.;Chatterjee, Sourav;Korley, LaShanda T. J.. And the article was included in Molecular Systems Design & Engineering in 2021.Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate This article mentions the following:
Inspired by Nature’s tunability driven by the modulation of structural organization, we utilize peptide motifs as an approach to tailor not only hierarchical structure, but also thermo-responsive shape memory properties of conventional polymeric materials. Specifically, poly(β-benzyl-L-aspartate)-b-poly(dimethylsiloxane)-b-poly(β-benzyl-L-aspartate) was incorporated as the soft segment in peptide-polyurea hybrids to manipulate hierarchical ordering through peptide secondary structure and a balance of inter- and intra-mol. hydrogen bonding. Employing these bioinspired peptidic polyureas, we investigated the influence of secondary structure on microphase-separated morphol., and shape fixity and recovery via attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR), small-angle X-ray scattering (SAXS) and dynamic mech. anal. (DMA). The β-sheet motifs promoted phase mixing through extensive inter-mol. hydrogen bonding between the hard block and peptide segments and provided an increased chain elasticity, resulting in decreased shape fixity compared to a non-peptidic control. In contrast, intra-mol. hydrogen bonding driven by the α-helical arrangements yielded a microphase-separated and hierarchically ordered morphol., leading to an increase in the shape fixing ratio. These results indicate that peptide secondary structure provides a convenient handle for tuning shape memory properties by regulating hydrogen bonding with the surrounding polyurea hard segment, wherein extent of hydrogen bonding and phase mixing between the peptidic block and hard segment dictate the resulting shape memory behavior. Furthermore, the ability to shift secondary structure as a function of temperature also was demonstrated as a pathway to influence shape memory response. This research highlights that peptide secondary conformation influences the hierarchical ordering and modulates the shape memory response of peptide-polymer hybrids. We anticipate that these findings will enable the design of smart bio-inspired materials with responsive and tailored function via a balance of hydrogen bonding character, structural organization, and mechanics. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate).
(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem