The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,6-Dichloropurine( cas:5451-40-1 ) is researched.Safety of 2,6-Dichloropurine.Zhuge, Juanping; Jiang, Ziyang; Jiang, Wei; Histand, Gary; Lin, Dongen published the article 《Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues》 about this compound( cas:5451-40-1 ) in Organic & Biomolecular Chemistry. Keywords: alkylbenzylpurinone preparation green chem; thioether purine oxidation iodine catalyst; methylarene purine oxidation iodine catalyst. Let’s learn more about this compound (cas:5451-40-1).
An efficient oxidative functionalization of purine-like substrates I (R = Et, Bn; R1 = H, Cl; R2 = OMe, Cl) with (thio)ethers such as oxolane, oxane, thiolane, etc. or methylarenes such as methylbenzene, 1,4-dimethylbenzene, ethylbenzene, etc. under mild conditions is described. Using I2 as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives II (R3 = Bn, oxolan-2-yl, thiolan-2-yl, etc.) with high atom- and step-economy and exceptional functional group tolerance.
After consulting a lot of data, we found that this compound(5451-40-1)Safety of 2,6-Dichloropurine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem