Synthetic Route of 16251-45-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, SMILES is O=C1O[C@H](C2=CC=CC=C2)[C@H](C)N1, belongs to oxazolidines compound. In a article, author is Ichikawa, Satoshi, introduce new discover of the category.
Development of Antibacterial Agents Active against Drug-resistant Bacterial Pathogens Based on Total Synthesis of Nucleoside Natural Products
Natural products are a rich source for drug development. However, some biologically relevant natural products possess rather large, complex or labile chemical structures compared to synthetic drugs, which limits chemical modification in a process pursuing a structure-activity relationship. Here we describe the rational simplification of the muraymycins and caprazamycins class of nucleoside natural products to address the issue associated with their molecular complexity. First, the systematic structure-activity relationship (SAR) study of the muraymycins using an Ugi four-component reaction was investigated. Our SAR study of the muraymycins suggests a probable mechanism for inhibition of the MraY. The predicted binding model would provide further direction towards the design of potent MraY inhibitors. Next, function-oriented synthesis (FOS) of caprazamycins was investigated. Based on the conformation-activity relationship study of a series of analogs 36-38, we designed the oxazolidine-containing uridine derivatives 41-44 by restricting the conformation of 36-38. As a result, the tert-butyl ester derivatives 43 were found to be the most active against a range of bacterial strains containing VRE with a similar potency to the parent natural products. These studies provide a novel strategy for the development of a new type of antibacterial agent effective against drug-resistant bacteria.
Synthetic Route of 16251-45-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16251-45-9 is helpful to your research.
Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem