Polymerized vorinostat mediated photodynamic therapy using lysosomal spatiotemporal synchronized drug release complex was written by Hu, Pengwei;Sun, Miao;Lu, Fengkun;Wang, Sizhen;Hou, Lei;Yu, Yingjie;Zhang, Yunchang;Sun, Linhong;Yao, Jianzhong;Yang, Feng;Wang, Chen;Ma, Zhiqiang. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.COA of Formula: C12H11NO5 This article mentions the following:
A combination of photodynamic therapy (PDT) and histone deacetylase inhibitor (HDACis) could potentiate single-mode anti-tumor activity of HDACis or PDT to inhibit tumor relapse and metastasis. However, poor solubility and heterogeneity in cellular uptake and tissue distribution hamper the dual mode antitumor effect. For a controlled drug release of photosensitizers and HDACis in cytoplasm, photosensitizer pyropheophorbide-a (Pyro) encapsulated in polymer polyethylene glycol-b-poly (asparaginyl-vorinostat) (simplified as Pyro@FPPS) are fabricated to achieve their lysosomal spatiotemporal synchronized release. With HDACis modeling PDT in vitro and in vivo, it seems that polymerized Vorinostat encapsulated photosensitizers significantly inhibited the tumor proliferation and metastasis by spatiotemporal synchronized drugs release, and Pyro@FPPS reported here reveals a promising prospect to exert drugs′ synergistic effect in a spatiotemporal synchronized manner and can be an effective strategy to inhibit tumor growth, recurrence and metastasis in clinic. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6COA of Formula: C12H11NO5).
(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.COA of Formula: C12H11NO5
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem