On January 31, 2013, Hoffmann, Matthias; Bischoff, Daniel; Dahmann, Georg; Klicic, Jasna; Schaenzle, Gerhard; Wollin, Stefan Ludwig Michael; Convers-Reignier, Serge Gaston; East, Stephen Peter; Marlin, Frederic Jacques; McCarthy, Clive; Scott, John published a patent.Synthetic Route of 97859-49-9 The title of the patent was Preparation of substituted quinolines as Syk inhibitors for therapy. And the patent contained the following:
The invention relates to substituted quinolines of formula I (wherein R1 is a (un)substituted C1-6-alkyl; R2 is halogen, (un)substituted Ph, (un)substituted five- or six-membered monocyclic heteroaryl, or (un)substituted bicyclic ring system), and their use as Syk inhibitors in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis. Synthetic procedures for preparing I are exemplified. Example compound II was prepared by reacting intermediates 7-phenylquinolin-5-ol and (R)-4-((S)-1-hydroxyethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one and deprotecting the compound formed. The examples compounds were tested in a human Syk kinase inhibition assay, and had IC50 values ≤ 1 μmol. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Synthetic Route of 97859-49-9
The Article related to preparation quinoline syk inhibitor therapy, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Synthetic Route of 97859-49-9
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem