On August 4, 2011, Hoffmann, Matthias; Dahmann, Georg; Fiegen, Dennis; Handschuh, Sandra; Klicic, Jasna; Linz, Guenter; Schaenzle, Gerhard; Schnapp, Andreas; East, Stephen P.; Mazanetz, Michael Philip; Scott, John; Walker, Edward published a patent.COA of Formula: C4H7NO3 The title of the patent was Preparation of substituted naphthyridines and their use as therapeutic Syk kinase inhibitors. And the patent contained the following:
The invention relates to new substituted naphthyridines of formula I, as well as pharmacol. acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is -O-R3 or -NR3R4, R3 is substituted C1-6-alkyl, R4 is H or C1-6-alkyl, and R2 is H, (un)substituted 5-10-membered aryl, (un)substituted 5-10-membered heteroaryl, etc., as well as pharmaceutical compositions containing these compounds Naphthyridines of formula I are particularly suitable for the treatment of respiratory complaints, allergic diseases, osteoporosis, gastrointestinal diseases, autoimmune diseases, inflammatory diseases and diseases of the peripheral or central nervous system, particularly for the treatment of asthma, allergic rhinitis, rheumatoid arthritis, allergic dermatitis and COPD. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting (R)-4-((R)-1-hydroxyethyl)pyrrolidine-2-one and III, had an IC50 of 0.0131 μM in an Syk kinase luminescence assay. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).COA of Formula: C4H7NO3
The Article related to preparation naphthyridine syk kinase inhibitor therapy, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.COA of Formula: C4H7NO3
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem