On November 30, 1985, Hamaguchi, Shigeki; Yamamura, Hiroshi; Hasegawa, Junzo; Watanabe, Kyoshi published a patent.Computed Properties of 97859-49-9 The title of the patent was Enzymic separation of optical isomers of 2-oxazolidinones. And the patent contained the following:
(R,S)-5-Acyloxymethyloxazolidin-2-ones I (R1 = H, (un)substituted aryl; R2 = (un)substituted alkyl) are treated with stereoselective esterases or microorganisms containing these enzymes to yield optically active 5-hydroxymethyloxazolidin-2-ones (II) and optically active but unreacted I (III). II and III are precursors for antibiotics. Thus, Pseudomonas aeruginosa lipoprotein lipase (L.P.L. Amano 3) 0.5 g and (R,S)-5-butanoyloxymethyloxazolidin-2-one 18.7 g were dissolved in 100 mL 0.1M phosphate buffer, pH 7.0. The mixture was stirred at 30° for 12 h. EtOAc extraction and fractionation by silica gel column chromatog. of the mixture yielded (R)-5-hydroxymethyloxazolidin-2-one and (S)-5-butanoyloxymethyloxazolidin-2-one (IV). The hydrolysis of IV (4 g) with NaOH yielded (S)-5-hydroxymethyloxazolidin-2-one (1.8 g). The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Computed Properties of 97859-49-9
The Article related to acyloxymethyloxazolidinone optical isomer separation esterase, oxazolidinone isomer separation esterase, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Computed Properties of 97859-49-9
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem