Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7789-45-9, is researched, SMILESS is [Cu+2].[Br-].[Br-], Molecular Br2CuJournal, ACS Macro Letters called Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound, Author is Zou, Miancheng; Zhao, Pengkun; Huo, Shuaidong; Goestl, Robert; Herrmann, Andreas, the main research direction is antibiotic polymer brush ultrasound.Name: Cupric bromide.
The ultrasound-mediated activation of drugs from macromol. architectures using the principles of polymer mechanochem. (sonopharmacol.) is a promising strategy to gain spatiotemporal control over drug activity. Yet, conceptual challenges limit the applicability of this method. Especially low drug-loading content and low mechanochem. efficiency require the use of high carrier mass concentrations and prolonged exposure to ultrasound. Moreover, the activated drug is generally shielded by the hydrodynamic coil of the attached polymer fragment leading to a decreased drug potency. Here we present a carrier design for the ultrasound-induced activation of vancomycin, which is deactivated with its H-bond-complementary peptide target sequence. We show that the progression from mechanophore-centered linear chains to mechanophore-decorated polymer brushes increases drug-loading content, mechanochem. efficiency, and drug potency. These results may serve as a design guideline for future endeavors in the field of sonopharmacol.
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Oxazolidine – Wikipedia,
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