Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion was written by Gao, Yunpeng;Wu, Guojiao;Zhou, Qi;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2018.Application of 888329-88-2 This article mentions the following:
A palladium-catalyzed oxygenative cross-coupling of ynamides and benzyl bromides has been developed. After subsequent hydrogenation, α,α-disubstituted amide derivatives, e. g., I, were obtained in good yields. Migratory insertion of α-oxo palladium carbene species, generated by intermol. oxidation, is proposed as the key step in this reaction. The study demonstrates the potential of ynamides to serve as carbene precursors in palladium-catalyzed C-C bond-forming cross-coupling reactions. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Application of 888329-88-2).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Application of 888329-88-2
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem