Final Thoughts on Chemistry for (R)-4-Benzyl-2-oxazolidinone

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According to our retrosynthesis, the main chain of the target molecule could be constructed using a C5 + C7 + C5 strategy. The key induction reaction afforded chiral methyl group moieties using different Evans templates with different configurations. Li2CuCl4 was effectively employed in the Csp3[sbnd]Csp3 coupling protocol. The target molecular was obtained in a 12.6% overall yield with nine steps in the longest linear route.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2040NO – PubChem